Progesterone and synthetic progestin, dienogest, induce apoptosis of human primary cultures of adenomyotic stromal cells
نویسندگان
چکیده
منابع مشابه
Progestin: Synthetic Progesterone
Progestin is a synthetic form of progesterone [4], a naturally occurring hormone [5], which plays an important role in the female reproductive cycle. During the 1950s two types of progestin [6] that were later used in birth control [7] pills were created, norethindrone [8] and norethynodrel [9]. In 1951 Carl Djerassi [10] developed norethindrone [8] at Syntex [11], SA Laboratories located in Me...
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Objective(s): Endometriosis is a complex gynecologic disease with unknown etiology. Noscapine has been introduced as a cancer cell suppressor. Endometriosis was considered as a cancer like disorder, The aim of present study was to investigate noscapine apoptotic effect on human endometriotic epithelial and stromal cells in vitro. Materials and Methods:In this in vitro study, endometrial biopsie...
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15 صفحه اولThe inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro.
Dienogest is a synthetic steroid that has been used as a progestogen in contraceptive pills and is currently being studied for its possible clinical use in the treatment of endometriosis. In this study, we investigated the direct effects of dienogest in differentiation and proliferation of human endometrial stromal cells (ESC) in vitro. After 12 days in the presence of oestradiol (10(-8) mol/l)...
متن کاملDecorin induced by progesterone plays a crucial role in suppressing endometriosis
Dienogest, a synthetic progestin, has been shown to be effective against endometriosis, although it is still unclear as to how it affects the ectopic endometrial cells. Decorin has been shown to be a powerful endogenous tumor repressor acting in a paracrine fashion to limit tumor growth. Our objectives were to examine the direct effects of progesterone and dienogest on the in vitro proliferatio...
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ژورنال
عنوان ژورنال: European Journal of Obstetrics & Gynecology and Reproductive Biology
سال: 2014
ISSN: 0301-2115
DOI: 10.1016/j.ejogrb.2014.05.031